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    <recommendedItem id="20100101_19_445"
                     title="Physician Charged in Michael Jackson Death"
                     score="0.012"
                     href="http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/tb/18368?impressionId=1265739498825"
                     
      &lt;p&gt;Conrad Robert Murray, MD, the physician attending Michael Jackson when the pop singer died of cardiac arrest last June, has been charged with involuntary manslaughter in Los Angeles.&lt;/p&gt;
&lt;p&gt;Murray was to be arraigned this afternoon. If convicted, he could receive a maximum prison term of four years.&lt;/p&gt;
&lt;p&gt;According to the L.A. County District Attorney&apos;s office, Murray &quot;did unlawfully, and without malice, kill Michael Joseph Jackson . . . in the commission of an unlawful act, not amounting to a felony; and in the commission of a lawful act which might have produced death, in an unlawful manner, and without due caution and circumspection.&quot;&lt;/p&gt;
&lt;p&gt;Witnesses said Murray was with Jackson when the 50-year-old singer collapsed at his rented home in Beverly Hills. Murray tried to revive Jackson there with CPR, then accompanied him to a hospital. Jackson was pronounced dead at the hospital without regaining consciousness.&lt;/p&gt;
&lt;p&gt;Subsequent statements from investigators indicated that Murry had injected Jackson with the anesthetic agent propofol earlier that day, apparently to help Jackson sleep.&lt;/p&gt;
&lt;p&gt;The singer had long complained of insomnia, according to news reports.&lt;/p&gt;
&lt;p&gt;After an autopsy, the Los Angeles county coroner&apos;s office &lt;a href=&quot;http://www.medpagetoday.com/ProductAlert/Prescriptions/15736&quot; mce_href=&quot;http://www.medpagetoday.com/ProductAlert/Prescriptions/15736&quot; target=&quot;_blank&quot;&gt;ruled in August&lt;/a&gt; that Jackson died of an overdose involving multiple drugs, including propofol and lorazepam (Ativan). Other drugs found in his system included midazolam, diazepam, lidocaine, and ephedrine.&lt;/p&gt;
&lt;p&gt;News reports indicated that other physicians besides Murray had prescribed drugs for Jackson. In addition to insomnia, the singer was believed to suffer from chronic pain related to burns suffered during the filming of a television commercial years earlier.&lt;/p&gt;
&lt;p&gt;The Reuters news service reported that Murray had told investigators he was not the first physician to give propofol to Jackson.&lt;/p&gt;
&lt;p&gt;In numerous public statements, Murray has maintained his innocence of wrongdoing.&lt;/p&gt;
&lt;p&gt;When Jackson died, he was about two weeks from beginning a series of 50 concerts in London, his first major performance effort in a decade. The posthumous concert film &quot;This Is It&quot; was filmed during rehearsals for the series.&lt;/p&gt;
&lt;p&gt;Although paparazzi photographs released in the months prior to his death portrayed the singer looking frail and gaunt  --  one showed him in a wheelchair  --  he appeared healthy in the film.&lt;/p&gt;

    </recommendedItem>
    <recommendedItem id="20100101_19_462"
                     title="BLOG: Good Conscience is Bad Business"
                     score="0.01"
                     href="http://www.medpagetoday.com/Blogs/18386?impressionId=1265739498825"
                     
      &lt;span style=&quot;font-family: Times; font-size: medium;&quot;&gt;&lt;div style=&quot;margin: 0px; padding: 0.6em; background-color: rgb(255, 255, 255); font-family: Georgia,&apos;Times New Roman&apos;,&apos;Bitstream Charter&apos;,Times,serif; font-style: normal; font-variant: normal; font-weight: normal; font-size: 13px; line-height: 19px; font-size-adjust: none; font-stretch: normal; -x-system-font: none;&quot;&gt;&lt;p&gt;I am going to state something that is completely obvious to most primary care physicians:  &lt;span style=&quot;font-style: italic;&quot; mce_style=&quot;font-style: italic;&quot; mce_name=&quot;em&quot;&gt;I do not accept Medicare and Medicaid patients because it is good business, I accept them despite the fact that it is bad business.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;In truth, I could make that statement about insurance as a whole; my life would be easier and my income would be less precarious if I did not accept any insurance.  If I did, I would charge a standard amount per visit based on time spent and require payment at the time of that visit.  This is totally obvious to me, and I suspect to most primary care physicians.  A huge part of our overhead comes from the fact that we are dealing with insurance.  A huge part of our headache and hassle comes from the fact that we are dealing with insurance.&lt;/p&gt;
&lt;p&gt;If I chose to post my charges up front and expected payment at the time of the visit, the impact to the business would be huge. As  it stands, the percentage of my collections that goes to overhead is between 50 and 60% (depending on the month).  A huge amount of that overhead is due to the need to hire a large billing staff to deal with the complexity of coding, billing, and documenting.  If I dropped insurance and charged a fixed amount, I could:&lt;/p&gt;
&lt;ol&gt;
&lt;li&gt;Cut my billing staff nearly to zero (someone would still have to do bookkeeping).&lt;/li&gt;
&lt;li&gt;Increase my payment per visit, which would allow me to see fewer patients per day.&lt;/li&gt;
&lt;li&gt;Document for the sake of patient care, and not for the sake of getting paid.&lt;/li&gt;
&lt;li&gt;Add extra services like email access and house calls without worrying about how I would get paid.&lt;/li&gt;
&lt;/ol&gt;
&lt;p&gt;In short, I could make my life better, my hassles less, and improve the quality of the care I offer.&lt;/p&gt;
&lt;p&gt;So why just single out Medicare and Medicaid?  Dropping insurance would force all of my M/M patients to find another doctor, while my patients with insurance could still choose to see me.  There are several reasons why this is possible for insured patients:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Insured patients generally have the option of filing for their own insurance (there are some that still don&apos;t allow this, but that number is dwindling with the decrease of HMO&apos;s).&lt;/li&gt;
&lt;li&gt;Insured patients could choose to just pay me cash if they choose.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;Can&apos;t Medicare/Medicaid patients do this?  No, for several reasons:&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;If a doctor does not accept M/M, the government will not pay anything for the visit regardless of who files.&lt;/li&gt;
&lt;li&gt;If the doctor &lt;span style=&quot;font-style: italic;&quot; mce_style=&quot;font-style: italic;&quot; mce_name=&quot;em&quot;&gt;does&lt;/span&gt; accept M/M, they are required to accept that payment and cannot charge anything outside of that (aside from the 20% not covered).  So if I charge a M/M patient $50 cash for a visit and am signed up to accept M/M, I am committing fraud.&lt;/li&gt;
&lt;li&gt;If I drop M/M, I cannot sign up for it again for 3 years, so the impact of that move is too large to consider at this time.&lt;/li&gt;
&lt;/ul&gt;
&lt;p&gt;So why in the world do I accept M/M still?  Why would I continue to make my life so difficult?  Two words: duty and calling. I view my seeing M/M patients as a social responsibility (especially Medicare).  These people need to be seen and they deserve good care, and despite the hassle and drain on income they cause, I make a reasonable income.  So far.&lt;/p&gt;
&lt;p&gt;Plus, I just like to take care of the elderly and the poor.  My personal reasons for going into medicine included both a desire to have a good job and the calling to care for people in need.  If I dropped M/M I would reject the calling for personal gain, which is something I can&apos;t do in good conscience at this time.&lt;/p&gt;
&lt;p&gt;The fact that the only thing keeping me accepting M/M is my conscience (and tolerance of pain) gives a really clear explanation as to why M/M are failing in the realm of primary care.  The government is not paying enough to make a good business case to accept M/M; instead it is relying on the consciences of primary care physicians like me who are willing to put up with the &lt;span style=&quot;font-style: italic;&quot; mce_style=&quot;font-style: italic;&quot; mce_name=&quot;em&quot;&gt;huge&lt;/span&gt; hassle of the system.  I am personally willing to continue on this course as long as (it doesn&apos;t get too much worse) but I have complete sympathy for PCP&apos;s who drop insurance and no longer see M/M patients.&lt;/p&gt;
&lt;p&gt;One of the biggest costs to our system is the high proportion of specialists to PCP&apos;s.  PCP&apos;s keep down cost, as their success is measured by keeping people healthy, away from specialists, and out of the hospital.  The system is just holding on with the PCP&apos;s we have; decreasing that number would be devastating and perhaps fatal to the system.  It&apos;s a very bad sign when the best business model for PCP&apos;s is to do something that, if done by all PCP&apos;s, would wreck the system.  Yet even physicians like myself, who have a strong sense of duty and social responsibility, wonder how long we can afford to take M/M.&lt;/p&gt;
&lt;p&gt;I am sure some are thinking: &lt;span style=&quot;font-style: italic;&quot; mce_style=&quot;font-style: italic;&quot; mce_name=&quot;em&quot;&gt;Poor Doctors!  They have to earn less money!  They have to actually have a conscience!  What a horrible thing! &lt;/span&gt;To that I answer with the fact that I &lt;span style=&quot;font-style: italic;&quot; mce_style=&quot;font-style: italic;&quot; mce_name=&quot;em&quot;&gt;have&lt;/span&gt; chosen to earn less money, increase my hassle, and live by my conscience.  At this time, most PCP&apos;s accepting M/M are doing the same.  But setting up a system that requires the choice between conscience and sanity, between doing the right thing and self-care, is foolish.  Pushing down M/M payments for PCP&apos;s will make a bad situation worse.&lt;/p&gt;
&lt;p&gt;That&apos;s bad politics, bad medicine, and bad business.&lt;/p&gt;
&lt;p&gt;Consider yourself warned, Washington.&lt;/p&gt;
&lt;/div&gt;
&lt;/span&gt;
    </recommendedItem>
    <recommendedItem id="20100101_19_461"
                     title="Limited Benefit Seen in CML Drug, FDA Says"
                     score="0.01"
                     href="http://www.medpagetoday.com/HematologyOncology/Leukemia/tb/18390?impressionId=1265739498825"
                     
      &lt;p&gt;WASHINGTON  --  Chronic myeloid leukemia (CML) patients who are resistant to imatinib (Gleevec) had a low response rate to treatment with omacetaxine (Omapro), according to Food and Drug Administration (FDA) reviewers.&lt;/p&gt;

&lt;p&gt;The FDA released its assessment of omacetaxine, made by ChemGenex Pharmaceuticals, in preparation for a meeting of an outside panel of oncology experts who will recommend whether the agency should approve the drug for imanitib-resistant CML patients with a Bcr-Abl T3151 mutation.&lt;/p&gt;
    &lt;p&gt;That meeting, original scheduled for Wednesday, was postponed when the federal government closed most Washington area offices because of snow. An FDA spokesman said no new date has been set.&lt;/p&gt;



&lt;p&gt;The agency does not have to follow the advice of its advisory panels, but it usually does.&lt;/p&gt;
&lt;p&gt;The Oncologic Drugs Advisory Committee will look at data from manufacturer ChemGenex&apos;s lone trial, which tested the safety and efficacy of subcutaneously administered omacetaxine in the target population.&lt;/p&gt;
&lt;p&gt;The trial divided 66 patients into disease stage cohorts of &quot;chronic phase,&quot; &quot;accelerated phase,&quot; or &quot;blast phase,&quot; and gave them 1.25 mg/m&lt;sup&gt;2&lt;/sup&gt; subcutaneous omacetaxine twice daily for 14 days every 28 days until hematologic response for induction therapy.&lt;/p&gt;
&lt;p&gt;If a patient achieved a complete hematologic response, hematologic improvement, or any cytogenetic response, the patient was transitioned to a maintenance does twice daily for seven days every 28 days.&lt;/p&gt;
&lt;p&gt;Researchers found: &lt;ul&gt; &lt;li&gt;For the chronic phase cohort of 40 patients, the major cytogenetic response rate was 15%, and the median duration of response was 7.7 months. &lt;/li&gt; &lt;li&gt;After a mean of nine months, 86% of the 49 chronic patients who were no longer controlling their diseases with imatinib had achieved a complete hematological response. &lt;/li&gt; &lt;li&gt;For the &quot;accelerated phase&quot; cohort of 16 patients, the major cytogenetic response rate was 6%, and the complete hematological response rate was 31%, with a median of duration of response of 22 weeks. &lt;/li&gt; &lt;li&gt;No patients responded in the more severe &quot;blast&quot; group, indicating omacetaxine works best among patients who are not as sick.&lt;/li&gt; &lt;li&gt;Overall, about 27% of patients achieved a major cytogenetic response, defined as absence of Bcr-Abl mutation in at least 35% of cells. About 18% of the patients had achieved a complete cytogenetic response, defined as all cells appearing to have lost the Bcr-Abl mutation.&lt;/li&gt; &lt;/ul&gt;&lt;/p&gt;
&lt;p&gt;&quot;The response rate observed in the efficacy study was low,&quot; FDA reviewers concluded in documents released in advance of Wednesday&apos;s meeting.&lt;/p&gt;
&lt;p&gt;However, ChemGenex researchers said, &quot;These results demonstrate that omacetaxine is an effective and durable therapy with rapid onset of action for CML patients with the Bcr-Abl T315I mutation.&quot;&lt;/p&gt;
&lt;p&gt;The most common adverse events in the trial were thrombocytopenia, anemia, diarrhea, and neutropenia.&lt;/p&gt;
&lt;p&gt;The FDA reviewers cited a number of concerns with the ChemGenex study, noting that the company planned to enroll 100 patients but submitted efficacy data from only 66, and then continued to enroll additional patients after the prespecified data cutoff.&lt;/p&gt;
&lt;p&gt;Also, the reviewers said there is no commercially available test to detect the T3151 mutation. And, although it was a requirement of the study that the patients have a confirmed T3151 mutation, the mutation status of 35% of the patients in the trial was not confirmed.&lt;/p&gt;
&lt;p&gt;There are currently no approved drugs that have been found to be effective at treating CML patients with the T315I mutation.&lt;/p&gt;
&lt;p&gt;&quot;Omacetaxine offers an important therapeutic option for the treatment of CML patients who have the T315I mutation, a population that has a clear unmet medical need and no proven treatment options,&quot; ChemGenex researchers wrote in the company&apos;s briefing document.&lt;/p&gt;

    </recommendedItem>
    <recommendedItem id="20100101_19_460"
                     title="Black Mothers at Increased Risk for Cardiomyopathy (CME/CE)"
                     score="0.01"
                     href="http://www.medpagetoday.com/Cardiology/Prevention/tb/18389?impressionId=1265739498825"
                     
      &lt;p&gt;African-American women have an increased risk of peripartum cardiomyopathy, researchers have found in a small, single-center Georgia study.&lt;/p&gt;
&lt;p&gt;Compared with healthy controls of other races, black women had a 15.7-fold increased risk of the dangerous heart condition (95% CI 3.5 to 70.6, &lt;em&gt;P&lt;/em&gt;&amp;lt;0.001), Mindy B. Gentry, MD, of the Medical College of Georgia Cardiovascular Center in Augusta, and colleagues reported online in the &lt;em&gt;Journal of the American College of Cardiology&lt;/em&gt;.&lt;/p&gt;
&lt;p&gt;The researchers said that the findings &quot;could not be explained by several other factors,&quot; including hypertension and smoking.&lt;/p&gt;
&lt;p&gt;&quot;We are unable to determine in this study whether genetic factors of race, or other complex environmental, social, economic, or other factors that are linked to race, account for the increased risk,&quot; the researchers wrote.&lt;/p&gt;
&lt;p&gt;Peripartum cardiomyopathy is a major cause of heart failure and cardiovascular mortality among women of child-bearing age, and can occur in women without preexisting heart disease.&lt;/p&gt;
&lt;p&gt;However, its risk factors have not yet been established, the researchers said.&lt;/p&gt;
&lt;p&gt;So they conducted a single-center, case-control study involving 28 women diagnosed with peripartum cardiomyopathy. Each case was matched with three healthy controls: all delivered babies within the same month.&lt;/p&gt;
&lt;p&gt;The researchers found that case incidence was 24 in 100,000 deliveries for non-blacks and 340 in 100,000 for African Americans.&lt;/p&gt;
&lt;p&gt;That relationship remained significant in multivariate analyses, controlling for other factors (OR 31.5, 95% CI 3.6 to 277.6).&lt;/p&gt;
&lt;p&gt;Other significant risk factors included hypertension (OR 10.8, 95% CI 2.6 to 44.4), being unmarried (OR 4.2, 95% CI 1.4 to 12.3), and having had more than two previous pregnancies (OR 2.9, 95% CI 1.1 to 7.4).&lt;/p&gt;
&lt;p&gt;It wasn&apos;t significant in the univariate analysis, but smoking during pregnancy was a significant risk factor in the multivariate analysis, the researchers said.&lt;/p&gt;
&lt;p&gt;Yet in a stratified analysis, &quot;none of these risk factors could explain solely the increased risk for this disorder among African-American women,&quot; they wrote.&lt;/p&gt;
&lt;p&gt;They noted that the frequency of cardiomyopathy was higher at their center than in previous reports, although it was comparable to the frequency in countries with more women of African descent (100 to 980 in 100,000 deliveries).&lt;/p&gt;
&lt;p&gt;&quot;These data and an analysis of previous reports provide strong, consistent evidence that the risk of peripartum cardiomyopathy is increased among women of African descent,&quot; they concluded. &quot;It is important to consider whether the increased risk is due to genetic factors, environmental factors, or both.&quot;&lt;/p&gt;
&lt;p&gt;The authors noted that the study was limited by a relatively small sample size.&lt;/p&gt;
&lt;div style=&quot;float:left;border-style:solid;border-width:1px;border-color:#8dabbc;font-family:arial;font-size:12px;background-color:#DBE9F2;padding:5px;&quot;&gt;&lt;p&gt;The researchers reported no conflicts of interest.&lt;/p&gt;&lt;/div&gt;&lt;div style=&quot;clear:both;&quot;&gt;&lt;/div&gt;
    </recommendedItem>
    <recommendedItem id="20100101_19_459"
                     title="Murtha Dead at 77"
                     score="0.01"
                     href="http://www.medpagetoday.com/Washington-Watch/Washington-Watch/tb/18388?impressionId=1265739498825"
                     
      &lt;p&gt;Representative John P. Murtha (D-Pa.), 77, long-time chairman of the House Appropriations Subcommittee on Defense, died yesterday afternoon from complications following a planned laparoscopic cholecystectomy, according to a statement from the congressman&apos;s office.&lt;/p&gt;
&lt;p&gt;He had been admitted to the intensive care unit at Virginia Hospital Center in Arlington on Jan. 31, days after surgeons at the National Naval Medical Center in Bethesda, Md., accidentally nicked his intestine during the operation, according to a report in &lt;em&gt;The Washington Post&lt;/em&gt;.&lt;/p&gt;
&lt;p&gt;In that same report, Rep. Bob Brady (D-Pa.), a close friend of Murtha&apos;s, said the congressman developed an infection and fever.&lt;/p&gt;
&lt;p&gt;Citing a request for privacy from the Murtha family and patient privacy laws, a spokesperson for the National Naval Medical Center declined to provide information on the operation.&lt;/p&gt;
&lt;p&gt;In a statement, Virginia Hospital Center said Murtha died &quot;despite aggressive critical care interventions.&quot;&lt;/p&gt;
&lt;p&gt;According to the American College of Surgeons, risks of laparoscopic cholecystectomy include bleeding, infection, injury to the bile duct, liver injury, numbness, hernia at the incision site, anesthesia complications, and puncture of the intestine.&lt;/p&gt;
&lt;p&gt;Death is extremely rare in healthy individuals, occurring in no more than one per 1,000 patients, according to the college.&lt;/p&gt;
&lt;p&gt;A 2009 Cochrane Review comparing laparoscopic versus open cholecystectomy for patients with symptomatic cholecystolithiasis found no difference in mortality in 38 trials. No patients died in the laparoscopic group and only 0.09% died in the open group.&lt;/p&gt;
&lt;p&gt;Severe complications were reported in 2.2% of the laparoscopic patients and 6.8% of the open patients.&lt;/p&gt;
&lt;p&gt;Murtha had recently become the longest serving member of Congress in Pennsylvania state history.&lt;/p&gt;
&lt;p&gt;First elected in 1974, Murtha, a former Marine, was the first Vietnam War combat veteran to serve in Congress, and he served as an advocate for the military throughout his career. He was also a prominent critic of the Iraq War.&lt;/p&gt;
&lt;p&gt;Murtha is survived by his wife, Joyce, and three children.&lt;/p&gt;

    </recommendedItem>
</recommendedContent>
